Role of the 3′ untranslated region in the regulation of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase gene expression by selenium supply
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چکیده
منابع مشابه
Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases.
Human glutathione transferases (GSTs) from Alpha (A), Mu (M) and Theta (T) classes exhibited glutathione peroxidase activity towards phospholipid hydroperoxide. The specific activities are in the order: GST A1-1>GST T1-1>GST M1-1>GST A2-2>GST A4-4. Using a specific and sensitive HPLC method, specific activities towards the phospholipid hydroperoxide,1-palmitoyl-2-(13-hydroper oxy-cis-9, trans-1...
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Phospholipid hydroperoxide glutathione peroxidase (PhGPx) is a unique selenoenzyme that directly detoxifies lipid hydroperoxides in situ. It therefore plays an important role in the protection of cellular membranes. PhGPx is expressed in most mammalian tissues. It is present as a mitochondrial form (L-PhGPx) and a cytosolic form (S-PhGPx). Overexpression of PhGPx has been shown to significantly...
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An Arabidopsis cDNA encoding putative phospholipid hydroperoxide glutathione peroxidase (PHGPX) was cloned and sequenced. The cDNA comprised 803 bp and included an open reading frame which encodes a polypeptide of 169 amino acid residues. The deduced amino acid sequence showed about 80 and 50% homology with plant putative PHGPXs and mammalian PHGPXs, respectively. Southern blot analysis suggest...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1996
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj3200891